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KMID : 0358520100220010069
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Korean Journal of Occupational and Environmental Medicine
2010 Volume.22 No. 1 p.69 ~ p.76
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A Case Study on the Effect of Chelation Therapy with Dimercaptosuccinic Acid (DMSA) for Lead Poisoning in an Adult
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Lee Yong-Jin
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Abstract
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Objectives: We wanted to investigate the efficacy of dimercaptosuccinic acid (DMSA) for the treatment of lead poisoning in an adult.
Methods: The chelation therapy was applied using oral DMSA after measuring the blood lead and performing, renal function tests, liver tests and a physical examination. This therapy with oral DMSA 30mg/kg/day was administered three times a day for 5 days to an adult patient with a pre-chelation blood lead concentration of 75 ㎍/dL. Testing was performed by assessing the daily blood lead level, the blood ZPP, the urine ALA, the symptoms and side effects were assessed by conducting a physical examination.
Results: DMSA therapy given for the duration of 5 days reduced the blood lead concentration from 75 ㎍/dL to 21.8 ㎍/dL. The blood ZPP concentration fell from 366 ㎍/dL to 300 ㎍/dL. The urine ALA concentration fell from 9.71 mg/L to 0.38 mg/L. In addition, the symptoms of headache, dizziness and abdominal pain that were induced by lead were improved after 2 days of chelation therapy. The vomiting did not improve after 5 days of chelation therapy, but this resolved 14 days following cessation of therapy. No adverse effects of DMSA therapy were seen.
Conclusions: Oral chelation therapy with DMSA 30 mg/kg/day is possible without being admitted to a hospital and it is generally effective, safe, and relatively inexpensive. DMSA provides a positive effect on adult patients who have lead poisoning.
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KEYWORD
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DMSA, Lead poisoning, Chelation therapy
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